To Be Led Astray?

Surrounded by Slit—How Forebrain Commissural Axons Can Be Led Astray

In Drosophila, Slit acts as a barrier preventing roundabout expressing axons from entering the midline and sorting contralaterally from ipsilaterally projecting axons. Hutson and Chien, Plump et al., and Bagri et al. (all in this issue of Neuron) use Slit knockout mice and zebrafish astray/Robo2 mutants to show that in vertebrates, Robo/Slit function to channel axons into specific pathways and ...

β Cells led astray by transcription factors and the company they keep.

Pancreatic β cells have one of the highest protein secretion burdens in the body, as these cells must synthesize and secrete insulin in proportion to postprandial rises in blood glucose. Remarkably, it is now becoming clear that adult β cells retain plasticity and can dedifferentiate into embryonic fates or adopt alternate islet endocrine cell identities. This property is especially important, ...

Zuma's legal advisors 'led him astray', turned healthcare professionals into criminals.

Schizophrenia: When neurons go astray

Recent prospective studies indicate that schizophrenia manifests itself in behavioural abnormalities much earlier than was previously thought, supporting the view that schizophrenia is a developmental disorder.

Paying People to Be Healthy

User Financial Incentives (UFIs) have emerged as a powerful tool for health promotion. Strong evidence suggests that large enough incentives paid to individuals, conditional on behaviour they can control, encourages more of the desired behaviour. However, such interventions can have unintended consequences for non-targeted behaviours. Implementation difficulties that result in individuals not u...